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Widely referenced in preclinical literature for its interaction with VEGF, FAK-paxillin, and nitric oxide pathways

The inclusion of proper controls (negative and positive controls) as well as preventive/protective versus treatment (i.e., treatment with urolithin A before versus after exposure) of sleep disturbances and disorders designs should be considered to evaluate potential benefits of urolithin A in the prevention and management of sleep conditions and their downstream adverse health effects

It should be noted that the human brain with its multimodal structure has undergone dramatic changes in brain regions such as the frontal and temporal lobes during evolution