Additionally, leflunomide treatment decreased the levels of MMP-1, MMP-9, and cartilage oligomeric matrix protein (COMP) in the serum of patients with RA (290)
GSH and pyroptosis Pyroptosis is a form of lytic cell death characterized by gasdermin-mediated plasma membrane pore formation, leading to osmotic swelling, membrane rupture, and the release of mature pro-inflammatory cytokines, including interleukin 1 beta (IL1B, also known as IL-1) and interleukin 18 (IL18)
PubMed Link Chen T, et al
To this end, they will determine the effects of aging and CR on the metabolism of Met, Cys and GSH in the C57BL/6 mouse model
This process engages a coordinated network of regulated cell death that extends beyond ferroptosis to include crosstalk with necroptosis and pyroptosis, while being critically modulated by ferritinophagy and the paradoxical role of defective mitophagy