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It also inhibited mitochondrial damage and cell apoptosis with higher Bcl-2/Bax and a lower mRNA expression of Bax , caspase-3 and caspase-9 , as well as higher mRNA expression of Bcl-2 , PI3K , and Akt , indicating that the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway could be a possible mechanism [72]

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