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Researchers coming from GLP-1 work will recognize this part of the mechanism

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J Neurosci 19:39523961 [DOI] [PMC free article] [PubMed] [Google Scholar] Wright JW, Wilson WL, Wakeling V, Boydstun AS, Jensen A, Kawas LH, Harding JW

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These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane

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