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This pathway involves the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2) by one of the four eIF2 kinases, reducing global protein synthesis and activating transcription factor ATF4 to restore homeostasis 145,146
Three DNA methyltransferase enzymes catalyze DNA methylation: Dnmt1, Dnmt3a, and Dnmt3b, which catalyze the transfer of a methyl group of S-adenosylmethionine (SAM) to the fifth carbon position of cytosine 26
Medically reviewed by: Jayden Lee, PharmD, EMBA Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes
doi: 10.1902/jop.2010.090486
Neuroscience 145, 14261438
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