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These include alterations in the monoaminergic system, changes in glutamatergic synaptic transmission, neuro-inflammation, alterations in the hypothalamic-pituitary-adrenocortical (HPA) axis, changes in brain-derived neurotrophic factor (BDNF), and hippocampal atrophy ( However, depression in AD is more specifically linked to deficits in certain brain regions and AD-related pathological changes

These conditions prevent the body from adequately absorbing oral B12 through the digestive tract

This has not been demonstrated in clinical practice with oral glutathione at standard supplemental doses, but preclinical evidence warrants caution in cancer patients undergoing active treatment [2][5]

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Brain GSH assessment Imaging and voxel selection Brain GSH levels were determined using a Philips Achieva 3.0-T whole-body scanner (Best, The Netherlands) equipped with a 32-channel SENSE phased-array head coil