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During an 8-day confinement period, 35 healthy adult participants who were current dual users of snus and combustible cigarettes used one study product each day for a defined period following overnight nicotine abstinence

Against our hypothesis, we did not find an effect of any of our interventions on acute smoking (i.e., groups that smoked directly before or after the acquisition) and even withdrawal (i.e., control group that required a restriction of smoking for 6 h after acquisition) on fear learning or generalization

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Smoking causes about 64,000 deaths and 400,000 hospital admissions a year in England alone, according to official estimates

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