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Although these familial PD cases are not common, and some may even have atypical features such as early onset ( 60 years), with clinical features and treatment response resembling idiopathic PD (Tan et al., 2019

## **What is a vitamin B-12 injection?** HCPCS code J3420 refers to an injection of vitamin B-12 (cyanocobalamin), a synthetic form of the vitamin used to treat pernicious anemia, dietary folate deficiency, and other specified B-group deficiencies

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Animal studies used oral doses of 550mg/kg to compensate for low bioavailability and first-pass metabolism