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Description

Meta-analyses have shown that AS-IV provides significant cardioprotective effects by reducing cardiac preload and afterload and inhibiting cardiac hypertrophy, with an effective therapeutic dose range of 1080 mg/kg/day (Zhang et al., 2023)

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Importantly, this regulation is context-dependent

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Since it is known that the sugar levels and the renal function affect the oxidative stress, the correlation between the sugar levels and the renal function and the oxidative stress parameters at T=0 (prior to the intervention) was investigated: the percentage of diabetic patients and the percentage of patients with impaired renal function was similar in the group of patients with normal oxidative stress values and in the group with high values

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Mol Pharmacol 36: 2228

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