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In animal models, supplementation prevented synaptic damage induced by chronic alcohol, according to a study by Shi Z et al

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Icariin treatment significantly inhibited the activity of apoptotic factors caspase-3 and Bcl-2-associated X protein (Bax)/Bcl-2, and reduced intracellular ROS and NO levels [67]

Vermorken, The pathophysiology of elevated vitamin B12 in clinical practice, QJM: An International Journal of Medicine, Volume 106, Issue 6, June 2013, Pages 505515, [Oxford Academic] Roman Pawlak, Scott James Parrott, Sudha Raj, Diana Cullum-Dugan, Debbie Lucus, How prevalent is vitamin B12 deficiency among vegetarians?, Nutrition Reviews, Volume 71, Issue 2, 1 February 2013, Pages 110117, Jatoi S, Hafeez A, Riaz SU, Ali A, Ghauri MI, Zehra M