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Journal of clinical biochemistry and nutrition, 47(3), 246255

In an inflammatory setting induced by IL-1, increased levels of hypoxia-inducible factor-2 (HIF-2) coupled with diminished GPX4 expression in chondrocytes increase their susceptibility to ferroptosis ( Figure 4 ) (80, 161)

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These play a significant role in neurotransmitter production, inflammation control and barrier regulation and their depletion is frequently observed in individuals with depression and anxiety further suggesting their relevance to mental health (Xiong R.-G

[DOI] [PubMed] [Google Scholar] 101.Xiao C.W., Hendry A., Kenney L., Bertinato J