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The downstream effects of RAGE-induced ROS in rat mesangial cells include reduced levels of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) (50) and increased activation of phosphoinositide 3-kinase (PI3K)/AKT pathway, which leads to activation of nuclear factor (NF)-B and the production of pro-inflammatory cytokines (51)

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Who should not use tirzepatide: Do not use tirzepatide if you or any family member has ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

doi:10.3389/fphar.2021.643972 [5] Hodges RE, Minich DM

[5] * Gezondheidsclaim in afwachting van goedkeuring door de Europese Commissie