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Although prior studies provide some insight for the intersection of nicotine use and depression, it had remained unclear as to whether symptoms related to depression led to the initiation of drug use, or if the effects of drug use (e.g., alterations in brain circuitry and/or induction of withdrawal symptoms during periods of abstinence) triggered the onset of depressive symptomology

Viviano M, Barresi E, Simeon FG, Costa B, Taliani S, Da Settimo F, et al

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