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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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Well explore the molecular basis of this selectivity, compare it to full-length growth hormone and other interventions, examine the clinical evidence for its targeted effects, and discuss practical implications for individuals seeking fat loss without metabolic or endocrine disruption

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