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These results suggest that IL-6 is necessary for the protective effect of caffeine on NAFLD in mice ( Caffeine has shown inhibitory effects in most of the preclinical studies on the effects of caffeine on NAFLD/non-alcoholic steatohepatitis (NASH) ( However, another researcher investigated the effects of caffeine and green coffee extract (GCE) on hepatic lipids in lean female rats with steatosis (Figure 2) ( via drinking water, diet, and gavage, and the doses vary across studies

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But the mechanism most people miss is oxidation, not just temperature

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