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Research has shown that taking different medications with the same mechanism of action can significantly increase the risk of side effects

A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillusa probiotic genus important for mucosal immunityas well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production

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However, continued activation of p53 triggers a pro-oxidation reaction that induces cell death

10.1016/j.cell.2019.03.032 4 AnandhanA.DodsonM.SchmidlinC