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Briefly, cultured ARPE-19 cells were depleted of GSH using: (1) incubation in cystine (Cys 2 )-free culture medium

After topical application, ketoconazole concentrations in plasma are low

The inclusion criteria were (1) research/review articles on sources and generation of reactive free radicals, (2) research/review articles with experimental data on ROS-associated diseases, (3) research/review articles with experimental data on antioxidant activity, (4) research/review articles exploring the mode of action of synthetic as well as natural antioxidants

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