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Microsecond electric pulses were able to disrupt the membranes of endocytotic vesicles, releasing the cytotoxic drug bleomycin ( 2+ electropermeation (CaEP) and calpain activity ( 3.7 Other cancers Beyond the malignancies mentioned above, PEFs demonstrate robust therapeutic efficacy in lung carcinoma, colon carcinoma, head and neck carcinoma, gastric carcinoma, and ovarian carcinoma, among others