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Golding points out that unless the enterohepatic circulation is disrupted, holotranscobalamin levels wont significantly decrease until the livers B12 stores are depleted (Golding, 2016)

Since your body only absorbs a small amount at once, excess B12 just gets flushed out

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Clinical deficiency with clearly low blood levels affects a smaller percentage, but a much larger group falls into a gray zone where levels are low enough to cause subtle symptoms without triggering an obvious diagnosis

Once again, the research doesnt show any additional benefits in these areas either (17)