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This study showed a nearly 5% improvement in cognitive function in Alzheimers patients in 8 weeks of 20g/day creatine supplementation

doi: 10.3109/00498258709043962

similarly, while the niacinamide in this compounded B-Complex is in a moderate dose, caution is advised in patients with untreated peptic ulcers or significant hepatic impairment, as even moderate niacin supplementation could aggravate these conditions (e.g

Additionally, it has been shown to modulate the serotonergic and dopaminergic systems within the brain