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Even used pouches can still contain enough residual nicotine to cause serious harm, especially to small dogs

MMWR Surveill Summ 2008;57:1-131

The p-value for assessing statistical significance was based on a t-test

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Similarly, aerosol inhalation can result in enhanced airway resistance [45] and increased sympathetic nervous system activity [46], factors contributing to elevated risk for the development of cardiopulmonary disorders [10, 47]