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Nicotine binds to nicotinic acetylcholine receptors in the central nervous system, stimulating dopaminergic reward pathways and playing a key role in the development of addiction 3

Abbreviations BMI body mass index CI confidence interval HR hazard ratio SCHS Singapore Chinese Health Study SD standard deviation Footnotes CONFLICT OF INTEREST STATEMENT All authors state that they have no conflict of interest

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It has also been found in ornamental plants such as blanket flower (Gaillardia sp.) , and zinnia and weeds