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Starting later, after atherosclerotic plaques have formed and endothelial estrogen receptors have downregulated, may not confer the same benefit and carries different risk

Oral doses of 1000 g deliver 5 to 40 g, even if taken with food

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Iron is considerably more toxic to cells expressing CYP2E1 than to cells not expressing this enzyme, and it is suspected that low concentrations of iron may act as a protective factor for CYP2E1 -induced injury

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