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In vivo rodent models have explored the pharmacokinetics and tissue distribution of Proxofim, examining whether the protease-resistant DRI backbone achieves sufficient systemic exposure and tissue penetration

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Consistent with our mass spectrometry results, CPSF subunits including CPSF160, CPSF100, CPSF73, CPSF30, Wdr33, and Fip1, all co-precipitated with ICP27 (Fig

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