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Wild-type IDH1 also influences additional metabolic pathways outside of the TCA cycle by increasing carbon flux into and out of this central metabolic pathway

When an unblinded clinician rates a self-limiting condition in a cohort that has already lost a quarter of its patients, a near-universal response rate is close to the expected result whether or not the drug does anything

High doses may interfere with circadian rhythms, affect mood, or interact with anticoagulants (Anderson and Maes 2012)

S2CID 43125880

A superimposition of our structure with the crystal structure (PDB ID: 2UZX) suggests that, upon the tethering of the N-terminal segment to the PSI and IPT1 domain of c-MET, the entire stalk region of c-MET rotates outward by ~20 (the pivot point is located at the linker between PSI and IPT1 domains), resulting in a more extended conformation (Supplementary Fig