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In DKD, upregulation of local angiotensin II in the renal tubule, activation of vascular endothelial growth factor (VEGF), and reduction of nitric oxide (NO) ( Activation of RAAS also leads to the release of aldosterone, a mineralocorticoid hormone, from the adrenal glands

[19] pointed out that this might result from the S-glutathionylation of several cysteine residues within the RyR1 molecule

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"PubChem Compound Summary for CID 3623358, Emideltide;delta Sleep Inducing Peptide" PubChem, Graf MV, Kastin AJ