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In fact, it has been reported that oxidative stress induces ER stress and the unfolded protein response (UPR) in lens epithelial cells, ultimately resulting in apoptosis 44

That process supports the liver directly, but it also helps protect other vital organs, including the brain, from the kind of long-term toxic burden that accumulates quietly over decades

This study showed that pelvic irradiation can substantially promote pyknosis in the neurons of DG and CA2 regions of the hippocampus, which strongly supports that pelvic irradiation can cause memory and cognitive effects indirectly

L-Carnitine enhances mitochondrial function by promoting increased fat burning

PDB entry 7sng), in which the C-terminus is also disordered (Wei et al