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Week 1-2: 0.5mg to 1mg once daily Week 3-4: 1mg once daily Week 5 onward: 1mg to 1.5mg once daily This gradual approach lets researchers assess tolerance

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CAN is characterized by damage to the nerve fibers that innervate the heart and blood vessels, leading to reduced heart rate variability (variability in the time interval between heartbeats) and increased risk of mortality (80)