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The fact is that this is the only copy, so far as we can determine, that has contemporary colored plates, and that is because it was intended for presentation. All other documented copies of the first edition have woodcut engravings, which are reproduced in black and white

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Writing in the Journal of Neurochemistry , researchers from the University of Missouri School of Medicine found that nicotine cancels out the sleep-inducing effects of alcohol. Previous research has shown that more than 85 percent of alcohol-dependent American adults were also dependent on nicotine

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