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The general principle: larger body mass means more adipose tissue to mobilize, more volume of distribution for the compound, and potentially higher receptor density

David Sinclair, a leading voice in longevity research, has stated: NAD+ is the closest we've gotten to a fountain of youth.[2] His research highlights how NAD+ activates pathways that mimic caloric restriction, a known extender of lifespan in models

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The appropriate dose is dictated entirely by the design of the experiment