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Assessment of the risk of immunogenicity is a major component in the development of biotherapeutic drugs and is also one of the factors taken into consideration in the overall benefit-risk evaluation

Its best used as part of a broader approach, including lifestyle changes, dietary adjustments, and, if necessary, medication

PMID: 24603446

Os dados disponveis provm essencialmente dos estudos animais, nos quais o peptdeo geralmente apresentou um perfil de toxicidade muito favorvel

As such, the regulatory feedback between haem/iron sequestration and interactions with the host plays an important role in all facets if NTHi pathogenesis (Rodrguez-Arce et al., 2019)