mBio 13, e0084222
(2012) demonstrated that It could improve cognitive function in models of Alzheimers disease by promoting neuronal repair and synapse formation, suggesting its potential as a therapeutic for neurodegenerative conditions
The combination is most useful for patients with one or more of the following: BMI of 30 or higher , or BMI 27 with at least one weight-related condition such as type 2 diabetes, hypertension, or sleep apnea History of fatigue, low mood, or brain fog on previous diets or weight loss attempts Metformin use for type 2 diabetes or pre-diabetes (chronic metformin reduces B12) Long-term proton pump inhibitor use such as omeprazole, pantoprazole, or lansoprazole Vegetarian or vegan diet with limited animal protein intake Adults over 50 , where B12 absorption naturally declines Active strength training or higher physical demands while on a calorie deficit Patients who dont fit any of these profiles can still take semaglutide alone, then add B12 if symptoms suggest it
van der Poll, T., van de Veerdonk, F
Ethics statement The studies involving human participants were reviewed and approved by the local ethics committee in Stockholm (2016/1485-32, amendment 2017/779-32)
