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Image: Brian Hagiwara/Getty Images About the Author Maureen Salamon, Executive Editor, Harvard Women's Health Watch About the Reviewers Toni Golen, MD, Editor in Chief, Harvard Women's Health Watch

Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)

Hard to say

Compounds that selectively kill senescent cells (senolytics) can treat different age-related pathologies 12

A 5X antibody working solution containing Anti-hHMGB1 mAV-SmBiT and Anti-hHMGB1 mAB-LgBiT was added (20 L) per well and incubated for 6090 min