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Ipamorelin is administered subcutaneously, which can lead to reactions at the injection site, such as induration, pain, or redness

274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

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