Recent studies further connect sustained Ca 2+ entry (via NMDAR or P2X7) to loss of mitochondrial membrane potential, increased mitochondrial ROS, and suppression of mitophagic clearance, collectively potentiating NLRP3 activation in microglia under HIV-related conditions [100]
That extra strain has real consequences
Individual protocols vary significantly
Mitochondria are important sites of ROS generation and fatty acid metabolism and provide specific lipid precursors for ferroptosis to occur in the cell
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