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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

doi: 10.1101/2025.07.07.25329844 56 ChanYLLiaoJCLiTLWuCJChiuYH

Notably, the expression of aromatase was upregulated significantly by BPA exposure, but exhibited a contrasting pattern of aromatase expression decline

By your mid-thirties, those pulses have already started shrinking