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Critical Reviews in Toxicology

Initially (pre-21st century), cigarettes were used for their "medicinal properties." However, mounting research and evidence show that these properties were often a byproduct of their addictive properties and placebo effects

Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study

It's about a mental disorder where by chance and happenstance dopamine pathway receptors have eight times greater affinity or attraction to nicotine than acetylcholine, the receptor's own neurotransmitter

Once in the brain, nicotine binds to receptors that release neurotransmitters, particularly dopaminea chemical that triggers feelings of pleasure and reward