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The Virginia's have been matured before being selected and then hot pressed to bring out a darker, more fuller flavour

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Social aspects: Chewing tobacco as a habit is also frowned upon

For ASH, this merger signals a significant shift in PMIs lobbying strategies as it actively promotes its new tobacco products (heated tobacco, snus)

To address possible pleiotropic effects, we applied pleiotropy-robust MR methods, including MR-Egger regression, which accounts for pleiotropy when examining the association between the exposure and outcome