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The presence of cognitive deficits correlated with microglial activation and the increased expression of neuro-inflammatory cytokines such as IL1, TNF and IFN, in the hippocampus and the prefrontal cortex regions of the brain (153)

Relationship Strain: Substance abuse can create distance and communication breakdowns with family and friends

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It may be demanding nicotine to end withdrawal and restore the chemical dependence it remembers.[6] If stress speeds the removal of nicotine from the body, withdrawal may arrive sooner

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