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This collagen transition phase typically peaks around weeks two through four and resolves by week six to eight as new collagen matures and cross-links properly

For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

Biochem Pharmacol 69:17651772

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