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Intracellular concentration of Ca 2+ increases, which triggers an inflammatory response

As a result, the B12 cannot bind with Intrinsic Factor (IF) and make its journey through the small intestine to be absorbed

The downstream result is a significant reduction in pro-inflammatory cytokine release, including TNF-alpha, IL-1beta, IL-6, and IL-8, all of which are elevated in psoriatic skin

After continuous research by scientists, various new pathways of ferroptosis independent of GPX4 have been discovered