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Given the differences in the PK characteristics between two formulations [15, 18, 19], the PK/PD relationships were explored at a range of dose levels: 1 mg, 2 mg, 3 mg, and 4 mg for the SC administration and 20 mg, 30 mg, 40 mg, and 50 mg for the SL administration

A typical initial course might involve one 3ml ampoule administered intramuscularly once daily or 2-3 times per week for several weeks, followed by a maintenance dose if necessary, based on individual response and clinical need

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This matters because it argues against simple collagen accumulation

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