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In a study by Rotondo Dottore, G., it was mentioned that H2O2 has a dual effect on fibroblast cell proliferation, with low concentrations of H2O2 inducing proliferation and releasing cytokines, while high concentrations of H2O2 are cytotoxic, when cell viability decreases (31)

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However, the conventionalization of GF mice with normal mouse stool leads to normalizing T-cell and NKT populations, and protection from kidney injury (Jang et al., 2009)