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Blind cage coding and automated video analysis (EthoVision, TopScan) are recommended Too low n : prior power analysis, n 8 minimum for rodent behavioural tests No positive control : without memantine, donepezil or scopolamine depending on the paradigm, impossible to judge if the model is functional No dose-response : a single tested dose is insufficient to conclude

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doi: 10.2903/j.efsa.2017.4780, 38

Abbreviations AI: Artificial intelligence CpG: Cytosinephosphateguanine DMG: Differentially methylated gene DMP: Differentially methylated position DMR: Differentially methylated region EWAS: Epigenome-wide association study GRADE: Grading of Recommendations Assessment, Development, and Evaluation PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analysis References Eisenberg V, Weil C, Chodick G, Shalev V