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Rational protein engineering through mutagenesis, guided by computer-aided approaches such as FRESCO (Wijma et al

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[5] Extracellular Matrix (ECM) Remodeling Research Studies examine: Matrix metalloproteinase activity and expression in fibroblast cultures Fibroblast migration, phenotype switching, and collagen synthesis pathways ERK/Akt/FAK signaling interactions with EGR-1-linked transcription Collagen organization and deposition mechanisms in tissue culture models ECM structural protein research in cellular repair systems Research investigates collagen organization processes and structural architecture development in controlled laboratory models