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The Phase 2b protocol used one dose per day for 12 weeks

American Journal of Obstetrics and Gynecology, 143(5), 543-550

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The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%)

TC2 is degraded within a lysosome, and free B 12 is released into the cytoplasm, where it is transformed into the bioactive coenzyme by cellular enzymes