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Heritability measurements have been derived from investigations on identical twins, fraternal twins and sibling concordance, including a survey of more than 2 million Swedish households in 2014, 71 which is the largest human-based ASD study to date, eventually estimating the heritability of ASD as ranging from 52% to 90%

The authors suggest that either methyl-B12 and adenosyl-B12 should be given together, or either cyano-B12 or hydroxo-B12 on their own, both of which can be converted into both active forms