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These dosing conventions emerged from practitioner experience and extrapolation from preclinical models

NNMT is involved in the conversion of nicotinamide, a form of vitamin B3, into methylated compounds

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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

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