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Am J Physiol Endocrinol Metabol

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1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence

Because B12 is water-soluble, the excess is rapidly excreted, so sustained benefit often requires repeated dosing or correction of a deficiency