(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice
Patients should be cautious with any product marketed online for fat loss, anti-aging, metabolism, or longevity without medical oversight
Bioinformatics 27 (21), 29572963
AOD 9604 is a synthetic peptide fragment derived from human growth hormone, while retatrutide is an investigational triple incretin receptor agonist currently in Phase 3 trials
Enzymatic-stability characterization of GH fragments
